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Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials.

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Title: Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials.
Authors: Heier JS; Ophthalmic Consultants of Boston, Boston, MA, USA., Lad EM; Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA., Holz FG; Department of Ophthalmology, University of Bonn, Bonn, Germany., Rosenfeld PJ; Department of Ophthalmology, University of Miami, Miami, FL, USA., Guymer RH; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia., Boyer D; Retina Vitreous Associates Medical Group, Los Angeles, CA, USA., Grossi F; Apellis Pharmaceuticals, Waltham, MA, USA., Baumal CR; Apellis Pharmaceuticals, Waltham, MA, USA., Korobelnik JF; Service d'Ophtalmologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France; Ophthalmology Department, University of Bordeaux, Bordeaux, France., Slakter JS; Department of Ophthalmology, New York University, New York, NY, USA., Waheed NK; New England Eye Center, Boston, MA, USA., Metlapally R; Apellis Pharmaceuticals, Waltham, MA, USA., Pearce I; Department of Ophthalmology, Royal Liverpool University Hospital, Liverpool, UK., Steinle N; California Retina Consultants, Santa Barbara, CA, USA., Francone AA; Charles Centro Oftalmológico, Buenos Aires, Argentina., Hu A; Cumberland Valley Retina Consultants, Hagerstown, MD, USA., Lally DR; New England Retina Consultants, Springfield, MA, USA., Deschatelets P; Apellis Pharmaceuticals, Waltham, MA, USA., Francois C; Apellis Pharmaceuticals, Waltham, MA, USA., Bliss C; Apellis Pharmaceuticals, Waltham, MA, USA., Staurenghi G; Department of Biomedical and Clinical Science, Ospedale Luigi Sacco University of Milan, Milan, Italy., Monés J; Institut de la Màcula, Centro Médico Teknon, Barcelona, Spain; Barcelona Macula Foundation: Research for Vision, Barcelona, Spain., Singh RP; Center for Ophthalmic Bioinformatics, Cleveland Clinic, Cleveland, OH, USA., Ribeiro R; Apellis Pharmaceuticals, Waltham, MA, USA., Wykoff CC; Retina Consultants of Texas, Houston, TX, USA; Blanton Eye Institute, Houston, TX, USA; Houston Methodist Hospital, Houston, TX, USA. Electronic address: charleswykoff@gmail.com.
Corporate Authors: OAKS and DERBY study investigators
Source: Lancet (London, England) [Lancet] 2023 Oct 21; Vol. 402 (10411), pp. 1434-1448.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials.
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  Data: <searchLink fieldCode="AU" term="%22Heier+JS%22">Heier JS</searchLink>; Ophthalmic Consultants of Boston, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lad+EM%22">Lad EM</searchLink>; Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Holz+FG%22">Holz FG</searchLink>; Department of Ophthalmology, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenfeld+PJ%22">Rosenfeld PJ</searchLink>; Department of Ophthalmology, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Guymer+RH%22">Guymer RH</searchLink>; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Boyer+D%22">Boyer D</searchLink>; Retina Vitreous Associates Medical Group, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Grossi+F%22">Grossi F</searchLink>; Apellis Pharmaceuticals, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Baumal+CR%22">Baumal CR</searchLink>; Apellis Pharmaceuticals, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Korobelnik+JF%22">Korobelnik JF</searchLink>; Service d'Ophtalmologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France; Ophthalmology Department, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Slakter+JS%22">Slakter JS</searchLink>; Department of Ophthalmology, New York University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Waheed+NK%22">Waheed NK</searchLink>; New England Eye Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Metlapally+R%22">Metlapally R</searchLink>; Apellis Pharmaceuticals, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pearce+I%22">Pearce I</searchLink>; Department of Ophthalmology, Royal Liverpool University Hospital, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Steinle+N%22">Steinle N</searchLink>; California Retina Consultants, Santa Barbara, CA, USA.<br /><searchLink fieldCode="AU" term="%22Francone+AA%22">Francone AA</searchLink>; Charles Centro Oftalmológico, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Hu+A%22">Hu A</searchLink>; Cumberland Valley Retina Consultants, Hagerstown, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lally+DR%22">Lally DR</searchLink>; New England Retina Consultants, Springfield, MA, USA.<br /><searchLink fieldCode="AU" term="%22Deschatelets+P%22">Deschatelets P</searchLink>; Apellis Pharmaceuticals, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Francois+C%22">Francois C</searchLink>; Apellis Pharmaceuticals, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bliss+C%22">Bliss C</searchLink>; Apellis Pharmaceuticals, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Staurenghi+G%22">Staurenghi G</searchLink>; Department of Biomedical and Clinical Science, Ospedale Luigi Sacco University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Monés+J%22">Monés J</searchLink>; Institut de la Màcula, Centro Médico Teknon, Barcelona, Spain; Barcelona Macula Foundation: Research for Vision, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Singh+RP%22">Singh RP</searchLink>; Center for Ophthalmic Bioinformatics, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ribeiro+R%22">Ribeiro R</searchLink>; Apellis Pharmaceuticals, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wykoff+CC%22">Wykoff CC</searchLink>; Retina Consultants of Texas, Houston, TX, USA; Blanton Eye Institute, Houston, TX, USA; Houston Methodist Hospital, Houston, TX, USA. Electronic address: charleswykoff@gmail.com.
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  Data: <searchLink fieldCode="CA" term="%22OAKS+and+DERBY+study+investigators%22">OAKS and DERBY study investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2023 Oct 21; Vol. 402 (10411), pp. 1434-1448.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE
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              Text: 2023 Oct 21
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