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Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.

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Bibliographic Details
Title: Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.
Authors: Thoma G; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Decoret O; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Vangrevelinghe E; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Trunzer M; PK Sciences, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland., Decker A; Chemical and Pharmaceutical Profiling, Global Drug Development, Novartis Pharma AG, 4002 Basel, Switzerland., Orjuela Leon A; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Beerli C; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Bruno S; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Hauchard A; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Paulat G; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Zerwes HG; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Hacini-Rachinel F; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Source: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 15042-15053. Date of Electronic Publication: 2023 Oct 31.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.3c01735