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Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.

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Title: Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.
Authors: Thoma G; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Decoret O; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Vangrevelinghe E; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Trunzer M; PK Sciences, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland., Decker A; Chemical and Pharmaceutical Profiling, Global Drug Development, Novartis Pharma AG, 4002 Basel, Switzerland., Orjuela Leon A; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Beerli C; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Bruno S; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Hauchard A; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Paulat G; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Zerwes HG; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland., Hacini-Rachinel F; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Source: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 15042-15053. Date of Electronic Publication: 2023 Oct 31.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.
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  Data: <searchLink fieldCode="AU" term="%22Thoma+G%22">Thoma G</searchLink>; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Decoret+O%22">Decoret O</searchLink>; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vangrevelinghe+E%22">Vangrevelinghe E</searchLink>; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Trunzer+M%22">Trunzer M</searchLink>; PK Sciences, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Decker+A%22">Decker A</searchLink>; Chemical and Pharmaceutical Profiling, Global Drug Development, Novartis Pharma AG, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Orjuela+Leon+A%22">Orjuela Leon A</searchLink>; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Beerli+C%22">Beerli C</searchLink>; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bruno+S%22">Bruno S</searchLink>; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hauchard+A%22">Hauchard A</searchLink>; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Paulat+G%22">Paulat G</searchLink>; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zerwes+HG%22">Zerwes HG</searchLink>; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hacini-Rachinel+F%22">Hacini-Rachinel F</searchLink>; Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 15042-15053. <i>Date of Electronic Publication: </i>2023 Oct 31.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.3c01735
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      – Code: eng
        Text: English
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            – D: 09
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              Text: 2023 Nov 09
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              Y: 2023
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