Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides.
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| Title: | Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. |
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| Authors: | Pandi A; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany. amir.pandi@mpi-marburg.mpg.de., Adam D; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.; Bundeswehr Institute of Microbiology, Munich, Germany., Zare A; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Trinh VT; Department of Chemistry, Philipps-University Marburg, Marburg, Germany., Schaefer SL; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany., Burt M; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Klabunde B; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Bobkova E; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Kushwaha M; Université Paris-Saclay, INRAe, AgroParisTech, Micalis Institute, Jouy-en-Josas, France., Foroughijabbari Y; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Braun P; Bundeswehr Institute of Microbiology, Munich, Germany.; German Center for Infection Research (DZIF), Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Immunology, Infection and Pandemic Research, Munich, Germany., Spahn C; Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Preußer C; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Philipps-University Marburg, Marburg, Germany.; Core Facility Extracellular Vesicles, Center for Tumor Biology and Immunology, Philipps-University of Marburg, Marburg, Germany., Pogge von Strandmann E; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Philipps-University Marburg, Marburg, Germany.; Core Facility Extracellular Vesicles, Center for Tumor Biology and Immunology, Philipps-University of Marburg, Marburg, Germany., Bode HB; Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.; Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany.; Department of Chemistry, Chemical Biology, Philipps-University Marburg, Marburg, Germany.; Senckenberg Gesellschaft für Naturforschung, Frankfurt, Germany.; SYNMIKRO Center of Synthetic Microbiology, Marburg, Germany., von Buttlar H; Bundeswehr Institute of Microbiology, Munich, Germany.; German Center for Infection Research (DZIF), Munich, Germany., Bertrams W; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Jung AL; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; Core Facility Flow Cytometry - Bacterial Vesicles, Philipps-University Marburg, Marburg, Germany., Abendroth F; Department of Chemistry, Philipps-University Marburg, Marburg, Germany., Schmeck B; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; SYNMIKRO Center of Synthetic Microbiology, Marburg, Germany.; Core Facility Flow Cytometry - Bacterial Vesicles, Philipps-University Marburg, Marburg, Germany.; Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Marburg, Philipps-University Marburg, Marburg, Germany.; Institute for Lung Health (ILH), Giessen, Germany.; Member of the German Center for Infectious Disease Research (DZIF), Marburg, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.; Institute for Biophysics, Goethe University Frankfurt, Frankfurt am Main, Germany., Vázquez O; Department of Chemistry, Philipps-University Marburg, Marburg, Germany.; SYNMIKRO Center of Synthetic Microbiology, Marburg, Germany., Erb TJ; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany. toerb@mpi-marburg.mpg.de.; SYNMIKRO Center of Synthetic Microbiology, Marburg, Germany. toerb@mpi-marburg.mpg.de. |
| Source: | Nature communications [Nat Commun] 2023 Nov 08; Vol. 14 (1), pp. 7197. Date of Electronic Publication: 2023 Nov 08. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-42434-9 |
