Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence.

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Title: Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence.
Authors: Savić R; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Yang J; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Koplev S; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., An MC; UNITY Biotechnology, South San Francisco, CA 94080, USA., Patel PL; UNITY Biotechnology, South San Francisco, CA 94080, USA., O'Brien RN; UNITY Biotechnology, South San Francisco, CA 94080, USA., Dubose BN; UNITY Biotechnology, South San Francisco, CA 94080, USA., Dodatko T; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Rogatsky E; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Sukhavasi K; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia., Ermel R; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia., Ruusalepp A; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia; Clinical Gene Networks AB, Stockholm, Sweden., Houten SM; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Kovacic JC; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia., Stewart AF; Diabetes Obesity Metabolism Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Yohn CB; UNITY Biotechnology, South San Francisco, CA 94080, USA., Schadt EE; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Laberge RM; UNITY Biotechnology, South San Francisco, CA 94080, USA., Björkegren JLM; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA; Clinical Gene Networks AB, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden., Tu Z; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Argmann C; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA. Electronic address: carmen.argmann@mssm.edu.
Source: Cell reports [Cell Rep] 2023 Nov 28; Vol. 42 (11), pp. 113371. Date of Electronic Publication: 2023 Nov 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2023.113371