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Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence.

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Title: Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence.
Authors: Savić R; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Yang J; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Koplev S; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., An MC; UNITY Biotechnology, South San Francisco, CA 94080, USA., Patel PL; UNITY Biotechnology, South San Francisco, CA 94080, USA., O'Brien RN; UNITY Biotechnology, South San Francisco, CA 94080, USA., Dubose BN; UNITY Biotechnology, South San Francisco, CA 94080, USA., Dodatko T; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Rogatsky E; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Sukhavasi K; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia., Ermel R; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia., Ruusalepp A; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia; Clinical Gene Networks AB, Stockholm, Sweden., Houten SM; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Kovacic JC; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia., Stewart AF; Diabetes Obesity Metabolism Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Yohn CB; UNITY Biotechnology, South San Francisco, CA 94080, USA., Schadt EE; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Laberge RM; UNITY Biotechnology, South San Francisco, CA 94080, USA., Björkegren JLM; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA; Clinical Gene Networks AB, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden., Tu Z; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA., Argmann C; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA. Electronic address: carmen.argmann@mssm.edu.
Source: Cell reports [Cell Rep] 2023 Nov 28; Vol. 42 (11), pp. 113371. Date of Electronic Publication: 2023 Nov 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence.
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  Data: <searchLink fieldCode="AU" term="%22Savić+R%22">Savić R</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.<br /><searchLink fieldCode="AU" term="%22Koplev+S%22">Koplev S</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22An+MC%22">An MC</searchLink>; UNITY Biotechnology, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Patel+PL%22">Patel PL</searchLink>; UNITY Biotechnology, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+RN%22">O'Brien RN</searchLink>; UNITY Biotechnology, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Dubose+BN%22">Dubose BN</searchLink>; UNITY Biotechnology, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Dodatko+T%22">Dodatko T</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.<br /><searchLink fieldCode="AU" term="%22Rogatsky+E%22">Rogatsky E</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.<br /><searchLink fieldCode="AU" term="%22Sukhavasi+K%22">Sukhavasi K</searchLink>; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Ermel+R%22">Ermel R</searchLink>; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Ruusalepp+A%22">Ruusalepp A</searchLink>; Department of Cardiac Surgery and The Heart Clinic, Tartu University Hospital, Tartu, Estonia; Clinical Gene Networks AB, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Houten+SM%22">Houten SM</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.<br /><searchLink fieldCode="AU" term="%22Kovacic+JC%22">Kovacic JC</searchLink>; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Stewart+AF%22">Stewart AF</searchLink>; Diabetes Obesity Metabolism Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Yohn+CB%22">Yohn CB</searchLink>; UNITY Biotechnology, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Schadt+EE%22">Schadt EE</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.<br /><searchLink fieldCode="AU" term="%22Laberge+RM%22">Laberge RM</searchLink>; UNITY Biotechnology, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Björkegren+JLM%22">Björkegren JLM</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA; Clinical Gene Networks AB, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Tu+Z%22">Tu Z</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.<br /><searchLink fieldCode="AU" term="%22Argmann+C%22">Argmann C</searchLink>; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA. Electronic address: carmen.argmann@mssm.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2023 Nov 28; Vol. 42 (11), pp. 113371. <i>Date of Electronic Publication: </i>2023 Nov 07.
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