Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model.
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| Title: | Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model. |
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| Authors: | Ahmad S; Department of Cell Biology and Physiology.; Eldec Pharmaceuticals, Chapel Hill, North Carolina., Wrennall JA; Department of Cell Biology and Physiology., Goriounova AS; Department of Pharmacology., Sekhri M; Department of Cell Biology and Physiology., Iskarpatyoti JA; Eldec Pharmaceuticals, Chapel Hill, North Carolina., Ghosh A; Department of Cell Biology and Physiology., Abdelwahab SH; Department of Cell Biology and Physiology., Voeller A; Department of Cell Biology and Physiology., Rai M; Department of Biomedical Engineering, North Carolina State University, Raleigh, North Carolina; and., Mahida RY; Birmingham Acute Care Research Group, University of Birmingham, Birmingham, United Kingdom., Krajewski K; Department of Biochemistry and Biophysics, and., Ignar DM; Eldec Pharmaceuticals, Chapel Hill, North Carolina., Greenbaum A; Department of Biomedical Engineering, North Carolina State University, Raleigh, North Carolina; and., Moran TP; Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Tilley SL; Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Thickett DR; Birmingham Acute Care Research Group, University of Birmingham, Birmingham, United Kingdom., Sassano MF; Department of Cell Biology and Physiology.; Eldec Pharmaceuticals, Chapel Hill, North Carolina., Tarran R; Department of Cell Biology and Physiology.; Eldec Pharmaceuticals, Chapel Hill, North Carolina. |
| Source: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Mar 15; Vol. 209 (6), pp. 703-715. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1535-4970 |
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| DOI: | 10.1164/rccm.202308-1393OC |
