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Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.

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Title: Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.
Authors: Schoof M; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Godbole S; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Albert TK; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Dottermusch M; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Walter C; Institute of Medical Informatics, University of Muenster, Muenster, Germany., Ballast A; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Qin N; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Olivera MB; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Göbel C; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Neyazi S; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Holdhof D; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Kresbach C; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Peter LS; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Epplen GD; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Thaden V; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Spohn M; Research Institute Children's Cancer Center, Hamburg, Germany., Blattner-Johnson M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Modemann F; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Oncology, Hematology and Bone marrow transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mynarek M; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rutkowski S; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Sill M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Varghese J; Institute of Medical Informatics, University of Muenster, Muenster, Germany., Afflerbach AK; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Eckhardt A; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Department of Radiotherapy & Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Münter D; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Verma A; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Struve N; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Radiotherapy & Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Jones DTW; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Remke M; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Neumann JE; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Kerl K; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Schüller U; Research Institute Children's Cancer Center, Hamburg, Germany. u.schueller@uke.de.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.
Source: Nature communications [Nat Commun] 2023 Nov 24; Vol. 14 (1), pp. 7717. Date of Electronic Publication: 2023 Nov 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-023-43564-w