View in EDS HTML Full Text PDF Full Text

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.

Saved in:
Bibliographic Details
Title: Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.
Authors: Schoof M; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Godbole S; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Albert TK; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Dottermusch M; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Walter C; Institute of Medical Informatics, University of Muenster, Muenster, Germany., Ballast A; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Qin N; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Olivera MB; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Göbel C; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Neyazi S; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Holdhof D; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Kresbach C; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Peter LS; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Epplen GD; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Thaden V; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Spohn M; Research Institute Children's Cancer Center, Hamburg, Germany., Blattner-Johnson M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Modemann F; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Oncology, Hematology and Bone marrow transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mynarek M; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rutkowski S; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Sill M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Varghese J; Institute of Medical Informatics, University of Muenster, Muenster, Germany., Afflerbach AK; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Eckhardt A; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Department of Radiotherapy & Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Münter D; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Verma A; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Struve N; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Radiotherapy & Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Jones DTW; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Remke M; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Neumann JE; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Kerl K; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Schüller U; Research Institute Children's Cancer Center, Hamburg, Germany. u.schueller@uke.de.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.
Source: Nature communications [Nat Commun] 2023 Nov 24; Vol. 14 (1), pp. 7717. Date of Electronic Publication: 2023 Nov 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 38001143
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Schoof+M%22">Schoof M</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Godbole+S%22">Godbole S</searchLink>; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Albert+TK%22">Albert TK</searchLink>; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Dottermusch+M%22">Dottermusch M</searchLink>; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Walter+C%22">Walter C</searchLink>; Institute of Medical Informatics, University of Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Ballast+A%22">Ballast A</searchLink>; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Qin+N%22">Qin N</searchLink>; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Olivera+MB%22">Olivera MB</searchLink>; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Göbel+C%22">Göbel C</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Neyazi+S%22">Neyazi S</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Holdhof+D%22">Holdhof D</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kresbach+C%22">Kresbach C</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Peter+LS%22">Peter LS</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Epplen+GD%22">Epplen GD</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Thaden+V%22">Thaden V</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Spohn+M%22">Spohn M</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Blattner-Johnson+M%22">Blattner-Johnson M</searchLink>; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Modemann+F%22">Modemann F</searchLink>; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Oncology, Hematology and Bone marrow transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mynarek+M%22">Mynarek M</searchLink>; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rutkowski+S%22">Rutkowski S</searchLink>; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sill+M%22">Sill M</searchLink>; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Varghese+J%22">Varghese J</searchLink>; Institute of Medical Informatics, University of Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Afflerbach+AK%22">Afflerbach AK</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Eckhardt+A%22">Eckhardt A</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Department of Radiotherapy & Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Münter+D%22">Münter D</searchLink>; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Verma+A%22">Verma A</searchLink>; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Struve+N%22">Struve N</searchLink>; Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Radiotherapy & Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+DTW%22">Jones DTW</searchLink>; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Remke+M%22">Remke M</searchLink>; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.; High-Throughput Drug Screening Core Facility, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Neumann+JE%22">Neumann JE</searchLink>; Center for Molecular Neurobiology (ZMNH), University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kerl+K%22">Kerl K</searchLink>; Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Schüller+U%22">Schüller U</searchLink>; Research Institute Children's Cancer Center, Hamburg, Germany. u.schueller@uke.de.; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2023 Nov 24; Vol. 14 (1), pp. 7717. <i>Date of Electronic Publication: </i>2023 Nov 24.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=38001143
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-023-43564-w
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 7717
    Titles:
      – TitleFull: Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Schoof M
      – PersonEntity:
          Name:
            NameFull: Godbole S
      – PersonEntity:
          Name:
            NameFull: Albert TK
      – PersonEntity:
          Name:
            NameFull: Dottermusch M
      – PersonEntity:
          Name:
            NameFull: Walter C
      – PersonEntity:
          Name:
            NameFull: Ballast A
      – PersonEntity:
          Name:
            NameFull: Qin N
      – PersonEntity:
          Name:
            NameFull: Olivera MB
      – PersonEntity:
          Name:
            NameFull: Göbel C
      – PersonEntity:
          Name:
            NameFull: Neyazi S
      – PersonEntity:
          Name:
            NameFull: Holdhof D
      – PersonEntity:
          Name:
            NameFull: Kresbach C
      – PersonEntity:
          Name:
            NameFull: Peter LS
      – PersonEntity:
          Name:
            NameFull: Epplen GD
      – PersonEntity:
          Name:
            NameFull: Thaden V
      – PersonEntity:
          Name:
            NameFull: Spohn M
      – PersonEntity:
          Name:
            NameFull: Blattner-Johnson M
      – PersonEntity:
          Name:
            NameFull: Modemann F
      – PersonEntity:
          Name:
            NameFull: Mynarek M
      – PersonEntity:
          Name:
            NameFull: Rutkowski S
      – PersonEntity:
          Name:
            NameFull: Sill M
      – PersonEntity:
          Name:
            NameFull: Varghese J
      – PersonEntity:
          Name:
            NameFull: Afflerbach AK
      – PersonEntity:
          Name:
            NameFull: Eckhardt A
      – PersonEntity:
          Name:
            NameFull: Münter D
      – PersonEntity:
          Name:
            NameFull: Verma A
      – PersonEntity:
          Name:
            NameFull: Struve N
      – PersonEntity:
          Name:
            NameFull: Jones DTW
      – PersonEntity:
          Name:
            NameFull: Remke M
      – PersonEntity:
          Name:
            NameFull: Neumann JE
      – PersonEntity:
          Name:
            NameFull: Kerl K
      – PersonEntity:
          Name:
            NameFull: Schüller U
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 24
              M: 11
              Text: 2023 Nov 24
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1