A medium-chain fatty acid analogue prevents hepatosteatosis and decreases inflammatory lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis.

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Title: A medium-chain fatty acid analogue prevents hepatosteatosis and decreases inflammatory lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis.
Authors: Cho BS; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Fligor SC; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Fell GL; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Secor JD; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Tsikis ST; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Pan A; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America., Yu LJ; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Ko VH; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Dao DT; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Anez-Bustillos L; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Hirsch TI; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Lund J; Department of Pharmacy, Section for Pharmacology and Pharmaceutical Biosciences, University of Oslo, Oslo, Norway., Rustan AC; Department of Pharmacy, Section for Pharmacology and Pharmaceutical Biosciences, University of Oslo, Oslo, Norway., Fraser DA; NorthSea Therapeutics, Amsterdam, Netherlands., Gura KM; Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Pharmacy and the Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, United States of America., Puder M; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America.
Source: PloS one [PLoS One] 2023 Dec 01; Vol. 18 (12), pp. e0295244. Date of Electronic Publication: 2023 Dec 01 (Print Publication: 2023).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0295244