Dapagliflozin-entresto protected kidney from renal hypertension via downregulating cell-stress signaling and upregulating SIRT1/PGC-1α/Mfn2-medicated mitochondrial homeostasis.

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Title: Dapagliflozin-entresto protected kidney from renal hypertension via downregulating cell-stress signaling and upregulating SIRT1/PGC-1α/Mfn2-medicated mitochondrial homeostasis.
Authors: Ko SF; Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301., Yang CC; Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301., Sung PH; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301., Cheng BC; Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301., Shao PL; Department of Nursing, Asia University, Taichung 41354., Chen YL; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301., Yip HK; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.; Department of Nursing, Asia University, Taichung 41354.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402.; School of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302.
Source: Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2023 Dec; Vol. 248 (23), pp. 2421-2439. Date of Electronic Publication: 2023 Dec 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699 (Electronic) Linking ISSN: 15353699 NLM ISO Abbreviation: Exp Biol Med (Maywood) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1535-3699
DOI:10.1177/15353702231198087