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The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.

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Title: The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.
Authors: Bull D; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom., Matte JC; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom., Navarron CM; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom., McIntyre R; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom., Whiting P; Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom., Katan M; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, United Kingdom., Ducotterd F; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom., Magno L; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom. Electronic address: l.magno@ucl.ac.uk.
Source: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Feb; Vol. 1870 (2), pp. 166978. Date of Electronic Publication: 2023 Dec 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-260X
DOI:10.1016/j.bbadis.2023.166978