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Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.

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Bibliographic Details
Title: Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Authors: Elsayed MSA; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Blake JF; Computational Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Boys ML; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Brown E; Pharmacology, Pfizer-Boulder, Boulder, Colorado 80301, United States., Chapsal BD; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Chicarelli MJ; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Cook AW; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Fell JB; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Fischer JP; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Hanson L; Enzymology, Pfizer-Boulder, Boulder, Colorado 80301, United States., Lemieux C; Cellular Biology, Pfizer-Boulder, Boulder, Colorado 80301, United States., Martinson MC; Enzymology, Pfizer-Boulder, Boulder, Colorado 80301, United States., McCown J; ADME Sciences, Pfizer-Boulder, Boulder, Colorado 80301, United States., McNulty OT; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Mejia MJ; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Neitzel NA; DMPK, Pfizer-Boulder, Boulder, Colorado 80301, United States., Otten JN; ADME Sciences, Pfizer-Boulder, Boulder, Colorado 80301, United States., Rodriguez ME; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Wilcox D; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Wong CE; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States., Zhou Y; Structural Biology, Pfizer-Boulder, Boulder, Colorado 80301, United States., Hinklin RJ; Medicinal Chemistry, Pfizer-Boulder, Boulder, Colorado 80301, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Nov 15; Vol. 14 (12), pp. 1673-1681. Date of Electronic Publication: 2023 Nov 15 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.3c00310