Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice.
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| Title: | Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice. |
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| Authors: | Xiong HJ; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Yu HQ; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Zhang J; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Fang L; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Wu D; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Lin XT; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Xie CM; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China. cmxie@tmmu.edu.cn. |
| Source: | Military Medical Research [Mil Med Res] 2023 Dec 20; Vol. 10 (1), pp. 68. Date of Electronic Publication: 2023 Dec 20. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Clinical Trial |
| Journal Info: | Publisher: BioMed Central Country of Publication: Netherlands NLM ID: 101643181 Publication Model: Electronic Cited Medium: Internet ISSN: 2054-9369 (Electronic) Linking ISSN: 20549369 NLM ISO Abbreviation: Mil Med Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2054-9369 |
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| DOI: | 10.1186/s40779-023-00501-8 |
