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Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice.

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Title: Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice.
Authors: Xiong HJ; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Yu HQ; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Zhang J; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Fang L; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Wu D; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Lin XT; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Xie CM; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China. cmxie@tmmu.edu.cn.
Source: Military Medical Research [Mil Med Res] 2023 Dec 20; Vol. 10 (1), pp. 68. Date of Electronic Publication: 2023 Dec 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Clinical Trial
Journal Info: Publisher: BioMed Central Country of Publication: Netherlands NLM ID: 101643181 Publication Model: Electronic Cited Medium: Internet ISSN: 2054-9369 (Electronic) Linking ISSN: 20549369 NLM ISO Abbreviation: Mil Med Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Elevated FBXL6 activates both wild-type KRAS and mutant KRAS<superscript>G12D</superscript> and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice.
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  Data: <searchLink fieldCode="AU" term="%22Xiong+HJ%22">Xiong HJ</searchLink>; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China.<br /><searchLink fieldCode="AU" term="%22Yu+HQ%22">Yu HQ</searchLink>; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China.<br /><searchLink fieldCode="AU" term="%22Fang+L%22">Fang L</searchLink>; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China.<br /><searchLink fieldCode="AU" term="%22Wu+D%22">Wu D</searchLink>; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China.<br /><searchLink fieldCode="AU" term="%22Lin+XT%22">Lin XT</searchLink>; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China.<br /><searchLink fieldCode="AU" term="%22Xie+CM%22">Xie CM</searchLink>; Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China. cmxie@tmmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101643181%22">Military Medical Research</searchLink> [Mil Med Res] 2023 Dec 20; Vol. 10 (1), pp. 68. <i>Date of Electronic Publication: </i>2023 Dec 20.
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  Data: Journal Article; Research Support, Non-U.S. Gov't; Clinical Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101643181 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2054-9369 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220549369%22">20549369 </searchLink><i>NLM ISO Abbreviation: </i>Mil Med Res <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1186/s40779-023-00501-8
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      – Code: eng
        Text: English
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        StartPage: 68
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      – TitleFull: Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice.
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            NameFull: Yu HQ
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            – D: 20
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              Text: 2023 Dec 20
              Type: published
              Y: 2023
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