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Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.

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Bibliographic Details
Title: Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
Authors: Smith CR; Mirati Therapeutics, San Diego, California 92130, United States., Chen D; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands., Christensen JG; Mirati Therapeutics, San Diego, California 92130, United States., Coulombe R; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada., Féthière J; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada., Gunn RJ; Mirati Therapeutics, San Diego, California 92130, United States., Hollander J; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands., Jones B; Mirati Therapeutics, San Diego, California 92130, United States., Ketcham JM; Mirati Therapeutics, San Diego, California 92130, United States., Khare S; Mirati Therapeutics, San Diego, California 92130, United States., Kuehler J; Mirati Therapeutics, San Diego, California 92130, United States., Lawson JD; Mirati Therapeutics, San Diego, California 92130, United States., Marx MA; Mirati Therapeutics, San Diego, California 92130, United States., Olson P; Mirati Therapeutics, San Diego, California 92130, United States., Pearson KE; Mirati Therapeutics, San Diego, California 92130, United States., Ren C; Mirati Therapeutics, San Diego, California 92130, United States., Tsagris D; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands., Ulaganathan T; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada., Van't Veer I; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands., Wang X; Mirati Therapeutics, San Diego, California 92130, United States., Ivetac A; Mirati Therapeutics, San Diego, California 92130, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Jan 11; Vol. 67 (1), pp. 774-781. Date of Electronic Publication: 2023 Dec 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.3c02140