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Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.

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Title: Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
Authors: Smith CR; Mirati Therapeutics, San Diego, California 92130, United States., Chen D; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands., Christensen JG; Mirati Therapeutics, San Diego, California 92130, United States., Coulombe R; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada., Féthière J; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada., Gunn RJ; Mirati Therapeutics, San Diego, California 92130, United States., Hollander J; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands., Jones B; Mirati Therapeutics, San Diego, California 92130, United States., Ketcham JM; Mirati Therapeutics, San Diego, California 92130, United States., Khare S; Mirati Therapeutics, San Diego, California 92130, United States., Kuehler J; Mirati Therapeutics, San Diego, California 92130, United States., Lawson JD; Mirati Therapeutics, San Diego, California 92130, United States., Marx MA; Mirati Therapeutics, San Diego, California 92130, United States., Olson P; Mirati Therapeutics, San Diego, California 92130, United States., Pearson KE; Mirati Therapeutics, San Diego, California 92130, United States., Ren C; Mirati Therapeutics, San Diego, California 92130, United States., Tsagris D; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands., Ulaganathan T; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada., Van't Veer I; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands., Wang X; Mirati Therapeutics, San Diego, California 92130, United States., Ivetac A; Mirati Therapeutics, San Diego, California 92130, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Jan 11; Vol. 67 (1), pp. 774-781. Date of Electronic Publication: 2023 Dec 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
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  Data: <searchLink fieldCode="AU" term="%22Smith+CR%22">Smith CR</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands.<br /><searchLink fieldCode="AU" term="%22Christensen+JG%22">Christensen JG</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Coulombe+R%22">Coulombe R</searchLink>; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada.<br /><searchLink fieldCode="AU" term="%22Féthière+J%22">Féthière J</searchLink>; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada.<br /><searchLink fieldCode="AU" term="%22Gunn+RJ%22">Gunn RJ</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Hollander+J%22">Hollander J</searchLink>; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands.<br /><searchLink fieldCode="AU" term="%22Jones+B%22">Jones B</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Ketcham+JM%22">Ketcham JM</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Khare+S%22">Khare S</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Kuehler+J%22">Kuehler J</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Lawson+JD%22">Lawson JD</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Marx+MA%22">Marx MA</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Olson+P%22">Olson P</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Pearson+KE%22">Pearson KE</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Ren+C%22">Ren C</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Tsagris+D%22">Tsagris D</searchLink>; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands.<br /><searchLink fieldCode="AU" term="%22Ulaganathan+T%22">Ulaganathan T</searchLink>; Inixium, 3000-275 Armand Frappier, Laval, Quebec H7V 4A7, Canada.<br /><searchLink fieldCode="AU" term="%22Van't+Veer+I%22">Van't Veer I</searchLink>; ZoBio BV, J.H. Oortweg 19, Leiden 2333 CH, Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.<br /><searchLink fieldCode="AU" term="%22Ivetac+A%22">Ivetac A</searchLink>; Mirati Therapeutics, San Diego, California 92130, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Jan 11; Vol. 67 (1), pp. 774-781. <i>Date of Electronic Publication: </i>2023 Dec 29.
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