Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules.

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Title: Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules.
Authors: Balasubramaniam M; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. mbalasubramaniam@uams.edu., Narasimhappagari J; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Liu L; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Ganne A; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Ayyadevara S; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Central Arkansas Veterans Healthcare System, Little Rock, AR, USA., Atluri R; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Ayyadevara H; University of Arkansas, Fayetteville, Fayetteville, AR, 72701, USA., Caldwell G; University of Alabama, Tuscaloosa, AL, 35487, USA., Shmookler Reis RJ; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Central Arkansas Veterans Healthcare System, Little Rock, AR, USA., Barger SW; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Central Arkansas Veterans Healthcare System, Little Rock, AR, USA., Griffin WST; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. GriffinSueT@uams.edu.; Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. GriffinSueT@uams.edu.
Source: Communications biology [Commun Biol] 2024 Jan 08; Vol. 7 (1), pp. 60. Date of Electronic Publication: 2024 Jan 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-024-05767-9