Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integration.
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| Title: | Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integration. |
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| Authors: | Yu Y; Helmholtz Institute for RNA-Based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, 97080, Germany., Gawlitt S; Helmholtz Institute for RNA-Based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, 97080, Germany., de Andrade E Sousa LB; Helmholtz AI, Helmholtz Zentrum München, Neuherberg, 85764, Germany., Merdivan E; Helmholtz AI, Helmholtz Zentrum München, Neuherberg, 85764, Germany., Piraud M; Helmholtz AI, Helmholtz Zentrum München, Neuherberg, 85764, Germany., Beisel CL; Helmholtz Institute for RNA-Based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, 97080, Germany.; Medical Faculty, University of Würzburg, Würzburg, 97080, Germany., Barquist L; Helmholtz Institute for RNA-Based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, 97080, Germany. lars.barquist@helmholtz-hiri.de.; Medical Faculty, University of Würzburg, Würzburg, 97080, Germany. lars.barquist@helmholtz-hiri.de. |
| Source: | Genome biology [Genome Biol] 2024 Jan 11; Vol. 25 (1), pp. 13. Date of Electronic Publication: 2024 Jan 11. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1474-760X |
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| DOI: | 10.1186/s13059-023-03153-y |
