BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes.

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Title: BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes.
Authors: Alcober-Boquet L; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Kraus N; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Huber LS; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Vutukuri R; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Fuhrmann DC; Faculty of Medicine, Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany., Stross C; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Schaefer L; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Scholich K; Faculty of Medicine, Institute of Clinical Pharmacology, Goethe University Frankfurt, Frankfurt, Germany., Zeuzem S; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Piiper A; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Schulz MH; Faculty of Medicine, Institute of Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt, Germany., Trebicka J; Department of Internal Medicine B, University Hospital Münster, Münster, Germany., Welsch C; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Ortiz C; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.
Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Mar 01; Vol. 326 (3), pp. C880-C892. Date of Electronic Publication: 2024 Jan 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1522-1563
DOI:10.1152/ajpcell.00413.2023