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BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes.

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Title: BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes.
Authors: Alcober-Boquet L; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Kraus N; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Huber LS; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Vutukuri R; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Fuhrmann DC; Faculty of Medicine, Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany., Stross C; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Schaefer L; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Scholich K; Faculty of Medicine, Institute of Clinical Pharmacology, Goethe University Frankfurt, Frankfurt, Germany., Zeuzem S; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Piiper A; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Schulz MH; Faculty of Medicine, Institute of Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt, Germany., Trebicka J; Department of Internal Medicine B, University Hospital Münster, Münster, Germany., Welsch C; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Ortiz C; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.
Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Mar 01; Vol. 326 (3), pp. C880-C892. Date of Electronic Publication: 2024 Jan 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes.
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  Data: <searchLink fieldCode="AU" term="%22Alcober-Boquet+L%22">Alcober-Boquet L</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kraus+N%22">Kraus N</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Huber+LS%22">Huber LS</searchLink>; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Vutukuri+R%22">Vutukuri R</searchLink>; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Fuhrmann+DC%22">Fuhrmann DC</searchLink>; Faculty of Medicine, Institute of Biochemistry I, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Stross+C%22">Stross C</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Schaefer+L%22">Schaefer L</searchLink>; Faculty of Medicine, Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Scholich+K%22">Scholich K</searchLink>; Faculty of Medicine, Institute of Clinical Pharmacology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Zeuzem+S%22">Zeuzem S</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Piiper+A%22">Piiper A</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Schulz+MH%22">Schulz MH</searchLink>; Faculty of Medicine, Institute of Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Trebicka+J%22">Trebicka J</searchLink>; Department of Internal Medicine B, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Welsch+C%22">Welsch C</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Ortiz+C%22">Ortiz C</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.
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  Data: <searchLink fieldCode="JN" term="%22100901225%22">American journal of physiology. Cell physiology</searchLink> [Am J Physiol Cell Physiol] 2024 Mar 01; Vol. 326 (3), pp. C880-C892. <i>Date of Electronic Publication: </i>2024 Jan 15.
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