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Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.

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Bibliographic Details
Title: Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.
Authors: Loughran HM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Schirripa KM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Roecker AJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Breslin MJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Tong L; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Fillgrove KL; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kuo Y; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Bleasby K; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Collier H; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Altman MD; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ford MC; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Newman JA; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Drolet RE; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cosden M; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Jinn S; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Flick RB; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Liu X; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Minnick C; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Watt ML; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Lemaire W; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Burlein C; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Adam GC; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Austin LA; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Marcus JN; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Smith SM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Fraley ME; Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Dec 21; Vol. 15 (1), pp. 123-131. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.3c00436