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Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.

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Title: Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.
Authors: Russo M; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy. Electronic address: marta.russo@ieo.it., Gualdrini F; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy. Electronic address: francesco.gualdrini@ieo.it., Vallelonga V; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Prosperini E; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Noberini R; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Pedretti S; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano 20133, Italy., Borriero C; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Di Chiaro P; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Polletti S; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Imperato G; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano 20133, Italy., Marenda M; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Ghirardi C; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Bedin F; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Cuomo A; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Rodighiero S; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Bonaldi T; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy; Department of Hematology and Hematology-Oncology (DIPO), Università degli Studi di Milano, Milano 20122, Italy., Mitro N; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano 20133, Italy., Ghisletti S; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy. Electronic address: serenamarialuisa.ghisletti@ieo.it., Natoli G; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy. Electronic address: gioacchino.natoli@ieo.it.
Source: Molecular cell [Mol Cell] 2024 Mar 07; Vol. 84 (5), pp. 967-980.e10. Date of Electronic Publication: 2024 Jan 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4164
DOI:10.1016/j.molcel.2023.12.033