Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology.

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Title: Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology.
Authors: Gödicke S; Department of Pediatric Hematolgoy and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg-Eppendorf, Hamburg, Germany., Kresbach C; Department of Pediatric Hematolgoy and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg-Eppendorf, Hamburg, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany., Ehlert M; Department of Pediatric Hematolgoy and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg-Eppendorf, Hamburg, Germany., Obrecht D; Department of Pediatric Hematolgoy and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Altendorf L; Department of Pediatric Hematolgoy and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg-Eppendorf, Hamburg, Germany., Hack K; Department of Pediatric Hematolgoy and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg-Eppendorf, Hamburg, Germany., von Hoff K; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin Institute of Health, Berlin, Germany.; Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark., Carén H; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden., Melcher V; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, 48149, Münster, Germany., Kerl K; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, 48149, Münster, Germany., Englinger B; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria.; Center for Cancer Research and Comprehensive Cancer Center, Medical University Vienna, 1090, Vienna, Austria., Filbin M; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Pajtler KW; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Gojo J; Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria., Pietsch T; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany., Rutkowski S; Department of Pediatric Hematolgoy and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schüller U; Department of Pediatric Hematolgoy and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.; Research Institute Children's Cancer Center, Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. u.schueller@uke.de.
Source: Acta neuropathologica [Acta Neuropathol] 2024 Jan 24; Vol. 147 (1), pp. 23. Date of Electronic Publication: 2024 Jan 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1432-0533
DOI:10.1007/s00401-023-02682-x