Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health.
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| Title: | Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health. |
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| Authors: | Zekavat SM; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jorshery SD; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Departments of Computer Science/Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON M5G 1M1, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Rauscher FG; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig 04103, Germany., Horn K; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany., Sekimitsu S; Tufts University School of Medicine, Boston, MA 02111, USA., Koyama S; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Nguyen TT; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Costanzo MC; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jang D; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kühnapfel A; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany., Shweikh Y; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA., Ye Y; Computational Biology and Bioinformatics Program, Yale School of Medicine, New Haven, CT 06511, USA., Raghu V; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Zhao H; Computational Biology and Bioinformatics Program, Yale School of Medicine, New Haven, CT 06511, USA.; School of Public Health, Yale University, New Haven, CT 06510, USA., Ghassemi M; Departments of Computer Science/Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON M5G 1M1, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Elze T; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA., Segrè AV; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wiggs JL; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Del Priore L; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510, USA., Scholz M; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig 04103, Germany., Wang JC; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510, USA.; Northern California Retina Vitreous Associates, Mountain View, CA 94040, USA., Natarajan P; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zebardast N; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2024 Jan 24; Vol. 16 (731), pp. eadg4517. Date of Electronic Publication: 2024 Jan 24. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adg4517 |
