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Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health.

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Title: Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health.
Authors: Zekavat SM; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jorshery SD; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Departments of Computer Science/Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON M5G 1M1, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Rauscher FG; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig 04103, Germany., Horn K; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany., Sekimitsu S; Tufts University School of Medicine, Boston, MA 02111, USA., Koyama S; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Nguyen TT; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Costanzo MC; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jang D; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kühnapfel A; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany., Shweikh Y; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA., Ye Y; Computational Biology and Bioinformatics Program, Yale School of Medicine, New Haven, CT 06511, USA., Raghu V; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Zhao H; Computational Biology and Bioinformatics Program, Yale School of Medicine, New Haven, CT 06511, USA.; School of Public Health, Yale University, New Haven, CT 06510, USA., Ghassemi M; Departments of Computer Science/Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON M5G 1M1, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Elze T; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA., Segrè AV; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wiggs JL; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Del Priore L; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510, USA., Scholz M; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig 04103, Germany., Wang JC; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510, USA.; Northern California Retina Vitreous Associates, Mountain View, CA 94040, USA., Natarajan P; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zebardast N; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Source: Science translational medicine [Sci Transl Med] 2024 Jan 24; Vol. 16 (731), pp. eadg4517. Date of Electronic Publication: 2024 Jan 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health.
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  Data: <searchLink fieldCode="AU" term="%22Zekavat+SM%22">Zekavat SM</searchLink>; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Jorshery+SD%22">Jorshery SD</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Departments of Computer Science/Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON M5G 1M1, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Rauscher+FG%22">Rauscher FG</searchLink>; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Horn+K%22">Horn K</searchLink>; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.<br /><searchLink fieldCode="AU" term="%22Sekimitsu+S%22">Sekimitsu S</searchLink>; Tufts University School of Medicine, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Koyama+S%22">Koyama S</searchLink>; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TT%22">Nguyen TT</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Costanzo+MC%22">Costanzo MC</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Jang+D%22">Jang D</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Burtt+NP%22">Burtt NP</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Kühnapfel+A%22">Kühnapfel A</searchLink>; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.<br /><searchLink fieldCode="AU" term="%22Shweikh+Y%22">Shweikh Y</searchLink>; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Ye+Y%22">Ye Y</searchLink>; Computational Biology and Bioinformatics Program, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Raghu+V%22">Raghu V</searchLink>; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Computational Biology and Bioinformatics Program, Yale School of Medicine, New Haven, CT 06511, USA.; School of Public Health, Yale University, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Ghassemi+M%22">Ghassemi M</searchLink>; Departments of Computer Science/Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON M5G 1M1, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Elze+T%22">Elze T</searchLink>; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Segrè+AV%22">Segrè AV</searchLink>; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Wiggs+JL%22">Wiggs JL</searchLink>; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Del+Priore+L%22">Del Priore L</searchLink>; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Scholz+M%22">Scholz M</searchLink>; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+JC%22">Wang JC</searchLink>; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510, USA.; Northern California Retina Vitreous Associates, Mountain View, CA 94040, USA.<br /><searchLink fieldCode="AU" term="%22Natarajan+P%22">Natarajan P</searchLink>; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Zebardast+N%22">Zebardast N</searchLink>; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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