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VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation.

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Title: VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation.
Authors: Kosmider O; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France. olivier.kosmider@aphp.fr.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France. olivier.kosmider@aphp.fr., Possémé C; Institut Pasteur, Université de Paris Cité, Translational Immunology Unit, Paris, France., Templé M; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France., Corneau A; Sorbonne Université, Faculté de Médecine, UMS037, PASS, Plateforme de Cytométrie de la Pitié-Salpêtrière CyPS, Paris, France., Carbone F; Université de Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, INSERM UMR 1163, Paris, France.; Labtech Single-Cell@Imagine, Imagine Institute, INSERM UMR 1163, Paris, France., Duroyon E; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France., Breillat P; Université de Paris Cité, INSERM, U970, PARCC, F-, Paris, France.; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France., Chirayath TW; Université de Paris Cité, INSERM, UMR-S 1132 BIOSCAR, Paris, France., Oules B; Department of Pathology, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France., Sohier P; Department of Pathology, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France., Luka M; Université de Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, INSERM UMR 1163, Paris, France.; Labtech Single-Cell@Imagine, Imagine Institute, INSERM UMR 1163, Paris, France., Gobeaux C; Biochemistry Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France., Lazaro E; Department of Internal Medicine, Bordeaux University Hospital-Haut-Lévêque, Pessac, France., Outh R; Department of Internal Medicine, Centre Hospitalier de Perpignan, Perpignan, France., Le Guenno G; Department of Internal Medicine, Clermont-Ferrand University Hospital, Clermont-Ferrand, France., Lifermann F; Department of Internal Medicine, Côte-d'Argent Hospital, Dax, France., Berleur M; Department of Internal Medicine, AP-HP, APHP-NUP, Hôpital Bichat, Paris, France., Le Mene M; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France., Friedrich C; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France., Lenormand C; Université de Strasbourg, Department of Dermatology, CHRU Strasbourg, Strasbourg, France., Weitten T; Department of Internal Medicine, Centre Hospitalier (CHICAS), Gap, France., Guillotin V; Department of Internal Medicine, Bordeaux University Hospital-Saint-André, Bordeaux, France., Burroni B; Department of Pathology, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France., Boussier J; Sorbonne University - 47-83 Boulevard de l'Hopital, Paris, France., Willems L; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Department, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France., Aractingi S; Dermatology Department, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France., Dionet L; Université de Paris Cité, INSERM, U970, PARCC, F-, Paris, France., Tharaux PL; Université de Paris Cité, INSERM, U970, PARCC, F-, Paris, France., Vergier B; Pathology Department, Bordeaux University Hospital-Haut-Lévêque, Pessac, France., Raynaud P; Pathology Department, Centre Hospitalier de Perpignan, Perpignan, France., Ea HK; Université de Paris Cité, INSERM, UMR-S 1132 BIOSCAR, Paris, France.; Rheumatology Department, AP- HP, Lariboisière Hospital, Paris, France., Ménager M; Université de Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, INSERM UMR 1163, Paris, France.; Labtech Single-Cell@Imagine, Imagine Institute, INSERM UMR 1163, Paris, France., Duffy D; Institut Pasteur, Université de Paris Cité, Translational Immunology Unit, Paris, France., Terrier B; Université de Paris Cité, INSERM, U970, PARCC, F-, Paris, France. benjamin.terrier@aphp.fr.; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France. benjamin.terrier@aphp.fr.
Source: Nature communications [Nat Commun] 2024 Jan 30; Vol. 15 (1), pp. 910. Date of Electronic Publication: 2024 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation.
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  Data: <searchLink fieldCode="AU" term="%22Kosmider+O%22">Kosmider O</searchLink>; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France. olivier.kosmider@aphp.fr.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France. olivier.kosmider@aphp.fr.<br /><searchLink fieldCode="AU" term="%22Possémé+C%22">Possémé C</searchLink>; Institut Pasteur, Université de Paris Cité, Translational Immunology Unit, Paris, France.<br /><searchLink fieldCode="AU" term="%22Templé+M%22">Templé M</searchLink>; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Corneau+A%22">Corneau A</searchLink>; Sorbonne Université, Faculté de Médecine, UMS037, PASS, Plateforme de Cytométrie de la Pitié-Salpêtrière CyPS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Carbone+F%22">Carbone F</searchLink>; Université de Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, INSERM UMR 1163, Paris, France.; Labtech Single-Cell@Imagine, Imagine Institute, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Duroyon+E%22">Duroyon E</searchLink>; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Breillat+P%22">Breillat P</searchLink>; Université de Paris Cité, INSERM, U970, PARCC, F-, Paris, France.; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Chirayath+TW%22">Chirayath TW</searchLink>; Université de Paris Cité, INSERM, UMR-S 1132 BIOSCAR, Paris, France.<br /><searchLink fieldCode="AU" term="%22Oules+B%22">Oules B</searchLink>; Department of Pathology, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sohier+P%22">Sohier P</searchLink>; Department of Pathology, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Luka+M%22">Luka M</searchLink>; Université de Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, INSERM UMR 1163, Paris, France.; Labtech Single-Cell@Imagine, Imagine Institute, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gobeaux+C%22">Gobeaux C</searchLink>; Biochemistry Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lazaro+E%22">Lazaro E</searchLink>; Department of Internal Medicine, Bordeaux University Hospital-Haut-Lévêque, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Outh+R%22">Outh R</searchLink>; Department of Internal Medicine, Centre Hospitalier de Perpignan, Perpignan, France.<br /><searchLink fieldCode="AU" term="%22Le+Guenno+G%22">Le Guenno G</searchLink>; Department of Internal Medicine, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Lifermann+F%22">Lifermann F</searchLink>; Department of Internal Medicine, Côte-d'Argent Hospital, Dax, France.<br /><searchLink fieldCode="AU" term="%22Berleur+M%22">Berleur M</searchLink>; Department of Internal Medicine, AP-HP, APHP-NUP, Hôpital Bichat, Paris, France.<br /><searchLink fieldCode="AU" term="%22Le+Mene+M%22">Le Mene M</searchLink>; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Friedrich+C%22">Friedrich C</searchLink>; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lenormand+C%22">Lenormand C</searchLink>; Université de Strasbourg, Department of Dermatology, CHRU Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Weitten+T%22">Weitten T</searchLink>; Department of Internal Medicine, Centre Hospitalier (CHICAS), Gap, France.<br /><searchLink fieldCode="AU" term="%22Guillotin+V%22">Guillotin V</searchLink>; Department of Internal Medicine, Bordeaux University Hospital-Saint-André, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Burroni+B%22">Burroni B</searchLink>; Department of Pathology, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France.<br /><searchLink fieldCode="AU" term="%22Boussier+J%22">Boussier J</searchLink>; Sorbonne University - 47-83 Boulevard de l'Hopital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Willems+L%22">Willems L</searchLink>; Université de Paris Cité, Institut Cochin, CNRS UMR8104, INSERM U1016, Paris, France.; Hematology Department, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Aractingi+S%22">Aractingi S</searchLink>; Dermatology Department, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dionet+L%22">Dionet L</searchLink>; Université de Paris Cité, INSERM, U970, PARCC, F-, Paris, France.<br /><searchLink fieldCode="AU" term="%22Tharaux+PL%22">Tharaux PL</searchLink>; Université de Paris Cité, INSERM, U970, PARCC, F-, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vergier+B%22">Vergier B</searchLink>; Pathology Department, Bordeaux University Hospital-Haut-Lévêque, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Raynaud+P%22">Raynaud P</searchLink>; Pathology Department, Centre Hospitalier de Perpignan, Perpignan, France.<br /><searchLink fieldCode="AU" term="%22Ea+HK%22">Ea HK</searchLink>; Université de Paris Cité, INSERM, UMR-S 1132 BIOSCAR, Paris, France.; Rheumatology Department, AP- HP, Lariboisière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ménager+M%22">Ménager M</searchLink>; Université de Paris Cité, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, INSERM UMR 1163, Paris, France.; Labtech Single-Cell@Imagine, Imagine Institute, INSERM UMR 1163, Paris, France.<br /><searchLink fieldCode="AU" term="%22Duffy+D%22">Duffy D</searchLink>; Institut Pasteur, Université de Paris Cité, Translational Immunology Unit, Paris, France.<br /><searchLink fieldCode="AU" term="%22Terrier+B%22">Terrier B</searchLink>; Université de Paris Cité, INSERM, U970, PARCC, F-, Paris, France. benjamin.terrier@aphp.fr.; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France. benjamin.terrier@aphp.fr.
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