Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

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Title: Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.
Authors: Crespo-Garcia S; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; École d'optométrie, University of Montreal, Montreal, Quebec, Canada., Fournier F; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Diaz-Marin R; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Klier S; UNITY Biotechnology, South San Francisco, CA, USA., Ragusa D; UNITY Biotechnology, South San Francisco, CA, USA., Masaki L; UNITY Biotechnology, South San Francisco, CA, USA., Cagnone G; Departments of Pediatrics Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada., Blot G; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Hafiane I; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Dejda A; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Rizk R; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Juneau R; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Buscarlet M; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Chorfi S; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Patel P; UNITY Biotechnology, South San Francisco, CA, USA., Beltran PJ; UNITY Biotechnology, South San Francisco, CA, USA., Joyal JS; Departments of Pediatrics Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada., Rezende FA; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Hata M; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Nguyen A; UNITY Biotechnology, South San Francisco, CA, USA., Sullivan L; UNITY Biotechnology, South San Francisco, CA, USA., Damiano J; UNITY Biotechnology, South San Francisco, CA, USA., Wilson AM; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Mallette FA; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; Department of Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., David NE; UNITY Biotechnology, South San Francisco, CA, USA., Ghosh A; UNITY Biotechnology, South San Francisco, CA, USA., Tsuruda PR; UNITY Biotechnology, South San Francisco, CA, USA., Dananberg J; UNITY Biotechnology, South San Francisco, CA, USA., Sapieha P; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. mike.sapieha@umontreal.ca.; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. mike.sapieha@umontreal.ca.; UNITY Biotechnology, South San Francisco, CA, USA. mike.sapieha@umontreal.ca.
Source: Nature medicine [Nat Med] 2024 Feb; Vol. 30 (2), pp. 443-454. Date of Electronic Publication: 2024 Feb 06.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-024-02802-4