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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

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Title: Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.
Authors: Crespo-Garcia S; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; École d'optométrie, University of Montreal, Montreal, Quebec, Canada., Fournier F; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Diaz-Marin R; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Klier S; UNITY Biotechnology, South San Francisco, CA, USA., Ragusa D; UNITY Biotechnology, South San Francisco, CA, USA., Masaki L; UNITY Biotechnology, South San Francisco, CA, USA., Cagnone G; Departments of Pediatrics Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada., Blot G; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Hafiane I; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Dejda A; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Rizk R; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Juneau R; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Buscarlet M; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Chorfi S; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Patel P; UNITY Biotechnology, South San Francisco, CA, USA., Beltran PJ; UNITY Biotechnology, South San Francisco, CA, USA., Joyal JS; Departments of Pediatrics Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada., Rezende FA; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Hata M; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Nguyen A; UNITY Biotechnology, South San Francisco, CA, USA., Sullivan L; UNITY Biotechnology, South San Francisco, CA, USA., Damiano J; UNITY Biotechnology, South San Francisco, CA, USA., Wilson AM; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., Mallette FA; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; Department of Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada., David NE; UNITY Biotechnology, South San Francisco, CA, USA., Ghosh A; UNITY Biotechnology, South San Francisco, CA, USA., Tsuruda PR; UNITY Biotechnology, South San Francisco, CA, USA., Dananberg J; UNITY Biotechnology, South San Francisco, CA, USA., Sapieha P; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. mike.sapieha@umontreal.ca.; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. mike.sapieha@umontreal.ca.; UNITY Biotechnology, South San Francisco, CA, USA. mike.sapieha@umontreal.ca.
Source: Nature medicine [Nat Med] 2024 Feb; Vol. 30 (2), pp. 443-454. Date of Electronic Publication: 2024 Feb 06.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.
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  Data: <searchLink fieldCode="AU" term="%22Crespo-Garcia+S%22">Crespo-Garcia S</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; École d'optométrie, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Fournier+F%22">Fournier F</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Diaz-Marin+R%22">Diaz-Marin R</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Klier+S%22">Klier S</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ragusa+D%22">Ragusa D</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Masaki+L%22">Masaki L</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cagnone+G%22">Cagnone G</searchLink>; Departments of Pediatrics Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Blot+G%22">Blot G</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Hafiane+I%22">Hafiane I</searchLink>; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Dejda+A%22">Dejda A</searchLink>; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Rizk+R%22">Rizk R</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Juneau+R%22">Juneau R</searchLink>; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Buscarlet+M%22">Buscarlet M</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Chorfi+S%22">Chorfi S</searchLink>; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Beltran+PJ%22">Beltran PJ</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Joyal+JS%22">Joyal JS</searchLink>; Departments of Pediatrics Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Rezende+FA%22">Rezende FA</searchLink>; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Hata+M%22">Hata M</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Nguyen+A%22">Nguyen A</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+L%22">Sullivan L</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Damiano+J%22">Damiano J</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+AM%22">Wilson AM</searchLink>; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Mallette+FA%22">Mallette FA</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.; Department of Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22David+NE%22">David NE</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+A%22">Ghosh A</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tsuruda+PR%22">Tsuruda PR</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dananberg+J%22">Dananberg J</searchLink>; UNITY Biotechnology, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sapieha+P%22">Sapieha P</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. mike.sapieha@umontreal.ca.; Department of Ophthalmology, Centre Universitaire d'Ophtalmologie (CUO-HMR) Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada. mike.sapieha@umontreal.ca.; UNITY Biotechnology, South San Francisco, CA, USA. mike.sapieha@umontreal.ca.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2024 Feb; Vol. 30 (2), pp. 443-454. <i>Date of Electronic Publication: </i>2024 Feb 06.
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