Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.

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Title: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.
Authors: Malla SB; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Byrne RM; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Lafarge MW; Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Corry SM; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Fisher NC; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Tsantoulis PK; Faculty of Medicine, Université de Genève, Geneva, Switzerland., Mills ML; Cancer Research UK Scotland Institute, Glasgow, UK., Ridgway RA; Cancer Research UK Scotland Institute, Glasgow, UK., Lannagan TRM; Cancer Research UK Scotland Institute, Glasgow, UK., Najumudeen AK; Cancer Research UK Scotland Institute, Glasgow, UK., Gilroy KL; Cancer Research UK Scotland Institute, Glasgow, UK., Amirkhah R; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Maguire SL; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Mulholland EJ; Centre for Human Genetics, University of Oxford, Oxford, UK., Belnoue-Davis HL; Centre for Human Genetics, University of Oxford, Oxford, UK., Grassi E; Candiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Viviani M; Candiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Rogan E; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Redmond KL; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Sakhnevych S; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., McCooey AJ; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Bull C; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Hoey E; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Sinevici N; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Hall H; Cancer Research UK Scotland Institute, Glasgow, UK., Ahmaderaghi B; School of Electronics, Electrical Engineering and Computer Science, Queen's University Belfast, Belfast, UK., Domingo E; Department of Oncology, University of Oxford, Oxford, Oxfordshire, UK., Blake A; Department of Oncology, University of Oxford, Oxford, Oxfordshire, UK., Richman SD; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Isella C; Candiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Miller C; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Bertotti A; Candiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Trusolino L; Candiolo Cancer Institute, FPO IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Loughrey MB; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Department of Cellular Pathology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK., Kerr EM; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Tejpar S; Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium., Maughan TS; Department of Oncology, University of Oxford, Oxford, Oxfordshire, UK., Lawler M; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Campbell AD; Cancer Research UK Scotland Institute, Glasgow, UK., Leedham SJ; Centre for Human Genetics, University of Oxford, Oxford, UK., Koelzer VH; Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Oncology, University of Oxford, Oxford, Oxfordshire, UK., Sansom OJ; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Dunne PD; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK. p.dunne@qub.ac.uk.; Cancer Research UK Scotland Institute, Glasgow, UK. p.dunne@qub.ac.uk.
Corporate Authors: S:CORT consortium
Source: Nature genetics [Nat Genet] 2024 Mar; Vol. 56 (3), pp. 458-472. Date of Electronic Publication: 2024 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1718
DOI:10.1038/s41588-024-01654-5