Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [14C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [14C]Thiocyanate.

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Title: Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [14C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [14C]Thiocyanate.
Authors: Gu C; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.) chuck.gu@biogen.com., Huang J; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Muste C; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Zhong J; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Walker GS; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Obach RS; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Shaffer CL; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.).
Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Apr 16; Vol. 52 (5), pp. 323-336. Date of Electronic Publication: 2024 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1521-009X
DOI:10.1124/dmd.123.001462