Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [14C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [14C]Thiocyanate.
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| Title: | Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [14C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [14C]Thiocyanate. |
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| Authors: | Gu C; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.) chuck.gu@biogen.com., Huang J; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Muste C; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Zhong J; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Walker GS; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Obach RS; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.)., Shaffer CL; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.). |
| Source: | Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Apr 16; Vol. 52 (5), pp. 323-336. Date of Electronic Publication: 2024 Apr 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 38360917 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [<superscript>14</superscript>C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [<superscript>14</superscript>C]Thiocyanate. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gu+C%22">Gu C</searchLink>; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.) chuck.gu@biogen.com.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.).<br /><searchLink fieldCode="AU" term="%22Muste+C%22">Muste C</searchLink>; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.).<br /><searchLink fieldCode="AU" term="%22Zhong+J%22">Zhong J</searchLink>; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.).<br /><searchLink fieldCode="AU" term="%22Walker+GS%22">Walker GS</searchLink>; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.).<br /><searchLink fieldCode="AU" term="%22Obach+RS%22">Obach RS</searchLink>; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.).<br /><searchLink fieldCode="AU" term="%22Shaffer+CL%22">Shaffer CL</searchLink>; Drug Metabolism and Pharmacokinetics (C.G., J.H., C.M.), External Innovation Unit (C.L.S.), and Physical Biochemistry (J.Z.), Biogen, Inc., Cambridge, Massachusetts and Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (G.S.W., R.S.O.). – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229421550%22">Drug metabolism and disposition: the biological fate of chemicals</searchLink> [Drug Metab Dispos] 2024 Apr 16; Vol. 52 (5), pp. 323-336. <i>Date of Electronic Publication: </i>2024 Apr 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Pharmacology+and+Experimental+Therapeutics%2C+etc%2E]%22">American Society for Pharmacology and Experimental Therapeutics, etc.] </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9421550 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-009X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200909556%22">00909556 </searchLink><i>NLM ISO Abbreviation: </i>Drug Metab Dispos <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1124/dmd.123.001462 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 323 Titles: – TitleFull: Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [14C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [14C]Thiocyanate. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gu C – PersonEntity: Name: NameFull: Huang J – PersonEntity: Name: NameFull: Muste C – PersonEntity: Name: NameFull: Zhong J – PersonEntity: Name: NameFull: Walker GS – PersonEntity: Name: NameFull: Obach RS – PersonEntity: Name: NameFull: Shaffer CL IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 04 Text: 2024 Apr 16 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1521-009X Numbering: – Type: volume Value: 52 – Type: issue Value: 5 Titles: – TitleFull: Drug metabolism and disposition: the biological fate of chemicals Type: main |
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