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Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.

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Title: Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Authors: Martinez HA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Koliesnik I; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Kaber G; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Reid JK; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada., Nagy N; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Barlow G; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Falk BA; Matrix Biology Program, Benaroya Research Institute, Seattle, WA, USA., Medina CO; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Hargil A; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Zihsler S; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Vlodavsky I; Technion Integrated Cancer Center, Technion, Haifa, Israel., Li JP; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden., Pérez-Cruz M; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Tang SW; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Meyer EH; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Wrenshall LE; Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA., Lord JD; Translational Research Program, Benaroya Research Institute, Seattle, WA, USA., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Palmer TD; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA., Steinman L; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA., Nepom GT; Immune Tolerance Network, Benaroya Research Institute, Seattle, WA, USA., Wight TN; Matrix Biology Program, Benaroya Research Institute, Seattle, WA, USA., Bollyky PL; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Kuipers HF; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. hedwich.kuipers@ucalgary.ca.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada. hedwich.kuipers@ucalgary.ca.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada. hedwich.kuipers@ucalgary.ca.; Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada. hedwich.kuipers@ucalgary.ca.
Source: Nature communications [Nat Commun] 2024 Feb 20; Vol. 15 (1), pp. 1564. Date of Electronic Publication: 2024 Feb 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
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  Data: <searchLink fieldCode="AU" term="%22Martinez+HA%22">Martinez HA</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Koliesnik+I%22">Koliesnik I</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kaber+G%22">Kaber G</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Reid+JK%22">Reid JK</searchLink>; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.<br /><searchLink fieldCode="AU" term="%22Nagy+N%22">Nagy N</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barlow+G%22">Barlow G</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Falk+BA%22">Falk BA</searchLink>; Matrix Biology Program, Benaroya Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Medina+CO%22">Medina CO</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hargil+A%22">Hargil A</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zihsler+S%22">Zihsler S</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vlodavsky+I%22">Vlodavsky I</searchLink>; Technion Integrated Cancer Center, Technion, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Li+JP%22">Li JP</searchLink>; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Pérez-Cruz+M%22">Pérez-Cruz M</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tang+SW%22">Tang SW</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+EH%22">Meyer EH</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wrenshall+LE%22">Wrenshall LE</searchLink>; Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lord+JD%22">Lord JD</searchLink>; Translational Research Program, Benaroya Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+KC%22">Garcia KC</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Palmer+TD%22">Palmer TD</searchLink>; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Steinman+L%22">Steinman L</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nepom+GT%22">Nepom GT</searchLink>; Immune Tolerance Network, Benaroya Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wight+TN%22">Wight TN</searchLink>; Matrix Biology Program, Benaroya Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bollyky+PL%22">Bollyky PL</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kuipers+HF%22">Kuipers HF</searchLink>; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. hedwich.kuipers@ucalgary.ca.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada. hedwich.kuipers@ucalgary.ca.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada. hedwich.kuipers@ucalgary.ca.; Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Canada. hedwich.kuipers@ucalgary.ca.
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