Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study.
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| Title: | Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study. |
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| Authors: | Ou AH; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Rosenthal SB; Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Adli M; Department of Psychiatry and Psychotherapy, Charité- Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.; Fliedner Klinik Berlin, Center for Psychiatry, Psychotherapy and Psychosomatic Medicine, Berlin, Germany., Akiyama K; Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan., Akula N; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Alda M; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.; National Institute of Mental Health, Klecany, Czech Republic., Amare AT; Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia., Ardau R; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy., Arias B; Department of Evolutive Biology, Ecology and Environmental Sciences, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain.; CIBER de Salud Mental, ISCIII, Madrid, Barcelona, Catalonia, Spain., Aubry JM; Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland., Backlund L; Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany., Baune BT; Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.; Department of Psychiatry, University of Münster, Münster, Germany., Bellivier F; INSERM UMR-S 1144-Université Paris Cité Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France., Benabarre A; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain., Bengesser S; Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., Bhattacharjee AK; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Biernacka JM; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Cervantes P; The Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada., Chen GB; The Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada., Chen HC; Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan., Chillotti C; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy., Cichon S; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland., Clark SR; Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia., Colom F; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain., Cousins DA; Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK., Cruceanu C; Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada., Czerski PM; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland., Dantas CR; Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil., Dayer A; Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland., Del Zompo M; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Degenhardt F; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany., DePaulo JR; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Étain B; INSERM UMR-S 1144-Université Paris Cité Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France., Falkai P; Institute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany., Fellendorf FT; Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., Ferensztajn-Rochowiak E; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland., Forstner AJ; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany., Frisén L; Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Child and Adolescent Psychiatry Research Center, Stockholm, Sweden., Frye MA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Fullerton JM; Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Gard S; Pôle de Psychiatrie Générale Universitaire, Centre Hospitalier Charles Perrens, Bordeaux, France., Garnham JS; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Goes FS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Grigoroiu-Serbanescu M; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Bucharest, Romania., Grof P; Mood Disorders Center of Ottawa, Ottawa, ON, Canada., Gruber O; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany., Hashimoto R; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan., Hauser J; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany., Herms S; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland., Hoffmann P; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland., Hofmann A; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany., Hou L; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Jamain S; Inserm U955, Psychiatrie Translationnelle, Créteil, France., Jiménez E; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain., Kahn JP; Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Laxou-Université de Lorraine, Nancy, France., Kassem L; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Kato T; Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan., Kittel-Schneider S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany., König B; Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria., Kuo PH; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan., Kusumi I; Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan., Lackner N; Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., Laje G; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Landén M; Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lavebratt C; Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Leboyer M; Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France., Leckband SG; Department of Pharmacy, VA San Diego Healthcare System, La Jolla, CA, USA., Jaramillo CAL; Department of Psychiatry, University of Antioquia, Medellín, Medellín, Colombia., MacQueen G; Department of Psychiatry, University of Calgary, Calgary, AB, Canada., Maj M; Department of Psychiatry, University of Naples SUN, Naples, Italy., Manchia M; Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Marie-Claire C; INSERM UMR-S 1144-Université Paris Cité Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France., Martinsson L; Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden., Mattheisen M; Department of Biomedicine, Aarhus University, Aarhus, Denmark., McCarthy MJ; Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, USA., McElroy SL; Department of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, OH, USA., McMahon FJ; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Mitchell PB; School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia., Mitjans M; Department of Genetics, Microbiology, and Statistics, Faculty of Biology and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, CIBER de Salud Mental, ISCIII, Madrid, Spain., Mondimore FM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Monteleone P; Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Nöthen MM; Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany., Novák T; National Institute of Mental Health, Klecany, Czech Republic., Ösby U; Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Ozaki N; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan., Papiol S; Ludwig-Maximilians-University of Munich, Munich, Germany., Perlis RH; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Pisanu C; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Potash JB; Department of Psychiatry, University of Iowa, Iowa City, IA, USA., Pfennig A; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany., Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany., Reininghaus EZ; Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Rybakowski JK; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland., Schalling M; Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Schofield PR; Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Schubert KO; Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia., Schulze TG; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.; Institute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Schweizer BW; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Seemüller F; Institute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany., Severino G; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Shekhtman T; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Veterans Administration, San Diego Healthcare System, San Diego, CA, USA., Shilling PD; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Shimoda K; Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan., Simhandl C; Bipolar Center, Wiener Neustadt, Austria., Slaney CM; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada., Squassina A; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Stamm T; Department of Psychiatry and Psychotherapy, Charité- Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany., Stopkova P; National Institute of Mental Health, Klecany, Czech Republic., Tighe SK; Department of Psychiatry, University of Iowa, Iowa City, IA, USA.; University of Iowa Carver College of Medicine and University of Iowa College of Public Health, VA Quality Scholars Program, Iowa City VA Hospital, Iowa City, IA, USA., Tortorella A; Department of Psychiatry, University of Naples SUN, Naples, Italy., Turecki G; Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada., Vieta E; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain., Volkert J; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany., Witt S; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Wray NR; The University of Queensland, Queensland Brain Institute, Brisbane, QLD, Australia., Wright A; School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia., Young LT; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Zandi PP; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Kelsoe JR; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. jkelsoe@health.ucsd.edu.; Veterans Administration, San Diego Healthcare System, San Diego, CA, USA. jkelsoe@health.ucsd.edu. |
| Source: | Translational psychiatry [Transl Psychiatry] 2024 Feb 23; Vol. 14 (1), pp. 109. Date of Electronic Publication: 2024 Feb 23. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2158-3188 |
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| DOI: | 10.1038/s41398-024-02811-4 |
