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Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability.

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Title: Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability.
Authors: Kearney PJ; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA.; University of California, San Diego, CA, USA., Zhang Y; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Liang M; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tan Y; Mass Spectrometry Facility, Department of Biochemistry and Molecular Biotechnology, UMASS Chan Medical School, Worcester, MA, USA.; DMPK Group, Merck, S. San Francisco, CA, USA., Kahuno E; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA., Conklin TL; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Regeneron, Albany, NY, USA., Fagan RR; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA.; University of California, San Francisco, CA, USA., Pavchinskiy RG; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA., Shaffer SA; Mass Spectrometry Facility, Department of Biochemistry and Molecular Biotechnology, UMASS Chan Medical School, Worcester, MA, USA., Yue Z; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Melikian HE; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA. haley.melikian@umassmed.edu.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA. haley.melikian@umassmed.edu.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Feb 23; Vol. 10 (1), pp. 41. Date of Electronic Publication: 2024 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kearney+PJ%22">Kearney PJ</searchLink>; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA.; University of California, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liang+M%22">Liang M</searchLink>; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; Mass Spectrometry Facility, Department of Biochemistry and Molecular Biotechnology, UMASS Chan Medical School, Worcester, MA, USA.; DMPK Group, Merck, S. San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kahuno+E%22">Kahuno E</searchLink>; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Conklin+TL%22">Conklin TL</searchLink>; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Regeneron, Albany, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fagan+RR%22">Fagan RR</searchLink>; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA.; University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pavchinskiy+RG%22">Pavchinskiy RG</searchLink>; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shaffer+SA%22">Shaffer SA</searchLink>; Mass Spectrometry Facility, Department of Biochemistry and Molecular Biotechnology, UMASS Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yue+Z%22">Yue Z</searchLink>; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Melikian+HE%22">Melikian HE</searchLink>; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA. haley.melikian@umassmed.edu.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA. haley.melikian@umassmed.edu.
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2024 Feb 23; Vol. 10 (1), pp. 41. <i>Date of Electronic Publication: </i>2024 Feb 23.
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