Evidence for disrupted copper availability in human spinal cord supports CuII(atsm) as a treatment option for sporadic cases of ALS.

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Title: Evidence for disrupted copper availability in human spinal cord supports CuII(atsm) as a treatment option for sporadic cases of ALS.
Authors: Hilton JBW; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia., Kysenius K; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia., Liddell JR; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia., Mercer SW; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia., Paul B; School of Geography, Earth and Atmospheric Sciences, The University of Melbourne, Victoria, 3010, Australia.; Elemental Scientific Lasers, LLC, 685 Old Buffalo Trail, Bozeman, MT, 59715, USA., Beckman JS; Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, 97331, USA., McLean CA; Department of Anatomical Pathology, The Alfred Hospital, Victoria, 3004, Australia., White AR; Mental Health Program, Department of Cell and Molecular Biology, Queensland Institute of Biomedical Research Berghofer, Herston, QLD, 4006, Australia., Donnelly PS; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010, Australia., Bush AI; Melbourne Dementia Research Centre, The University of Melbourne and Florey Institute of Neuroscience and Mental Health, Victoria, 3010, Australia., Hare DJ; Atomic Medicine Initiative, University of Technology Sydney, Ultimo, NSW, 2007, Australia., Roberts BR; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA., Crouch PJ; Department of Anatomy and Physiology, The University of Melbourne, Victoria, 3010, Australia. pjcrouch@unimelb.edu.au.
Source: Scientific reports [Sci Rep] 2024 Mar 11; Vol. 14 (1), pp. 5929. Date of Electronic Publication: 2024 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-024-55832-w