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Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.

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Bibliographic Details
Title: Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
Authors: Ketcham JM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Harwood SJ; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Aranda R; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Aloiau AN; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Bobek BM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Briere DM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Burns AC; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Caddell Haatveit K; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Calinisan A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Clarine J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Elliott A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Engstrom LD; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Gunn RJ; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Ivetac A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Jones B; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Kuehler J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Lawson JD; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Nguyen N; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Parker C; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Pearson KE; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Rahbaek L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Saechao B; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Wang X; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Waters A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Waters L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Watkins AH; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Olson P; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Smith CR; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Christensen JG; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Marx MA; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4936-4949. Date of Electronic Publication: 2024 Mar 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.4c00078