View in EDS

Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.

Saved in:
Bibliographic Details
Title: Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
Authors: Ketcham JM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Harwood SJ; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Aranda R; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Aloiau AN; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Bobek BM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Briere DM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Burns AC; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Caddell Haatveit K; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Calinisan A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Clarine J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Elliott A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Engstrom LD; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Gunn RJ; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Ivetac A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Jones B; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Kuehler J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Lawson JD; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Nguyen N; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Parker C; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Pearson KE; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Rahbaek L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Saechao B; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Wang X; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Waters A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Waters L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Watkins AH; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Olson P; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Smith CR; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Christensen JG; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Marx MA; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4936-4949. Date of Electronic Publication: 2024 Mar 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 38477582
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Ketcham+JM%22">Ketcham JM</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Harwood+SJ%22">Harwood SJ</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Aranda+R%22">Aranda R</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Aloiau+AN%22">Aloiau AN</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Bobek+BM%22">Bobek BM</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Briere+DM%22">Briere DM</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Burns+AC%22">Burns AC</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Caddell+Haatveit+K%22">Caddell Haatveit K</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Calinisan+A%22">Calinisan A</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Clarine+J%22">Clarine J</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Elliott+A%22">Elliott A</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Engstrom+LD%22">Engstrom LD</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Gunn+RJ%22">Gunn RJ</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ivetac+A%22">Ivetac A</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Jones+B%22">Jones B</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Kuehler+J%22">Kuehler J</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Lawson+JD%22">Lawson JD</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+N%22">Nguyen N</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Parker+C%22">Parker C</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Pearson+KE%22">Pearson KE</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Rahbaek+L%22">Rahbaek L</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Saechao+B%22">Saechao B</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Waters+A%22">Waters A</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Waters+L%22">Waters L</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Watkins+AH%22">Watkins AH</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Olson+P%22">Olson P</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Smith+CR%22">Smith CR</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Christensen+JG%22">Christensen JG</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Marx+MA%22">Marx MA</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4936-4949. <i>Date of Electronic Publication: </i>2024 Mar 13.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=38477582
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.4c00078
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 4936
    Titles:
      – TitleFull: Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ketcham JM
      – PersonEntity:
          Name:
            NameFull: Harwood SJ
      – PersonEntity:
          Name:
            NameFull: Aranda R
      – PersonEntity:
          Name:
            NameFull: Aloiau AN
      – PersonEntity:
          Name:
            NameFull: Bobek BM
      – PersonEntity:
          Name:
            NameFull: Briere DM
      – PersonEntity:
          Name:
            NameFull: Burns AC
      – PersonEntity:
          Name:
            NameFull: Caddell Haatveit K
      – PersonEntity:
          Name:
            NameFull: Calinisan A
      – PersonEntity:
          Name:
            NameFull: Clarine J
      – PersonEntity:
          Name:
            NameFull: Elliott A
      – PersonEntity:
          Name:
            NameFull: Engstrom LD
      – PersonEntity:
          Name:
            NameFull: Gunn RJ
      – PersonEntity:
          Name:
            NameFull: Ivetac A
      – PersonEntity:
          Name:
            NameFull: Jones B
      – PersonEntity:
          Name:
            NameFull: Kuehler J
      – PersonEntity:
          Name:
            NameFull: Lawson JD
      – PersonEntity:
          Name:
            NameFull: Nguyen N
      – PersonEntity:
          Name:
            NameFull: Parker C
      – PersonEntity:
          Name:
            NameFull: Pearson KE
      – PersonEntity:
          Name:
            NameFull: Rahbaek L
      – PersonEntity:
          Name:
            NameFull: Saechao B
      – PersonEntity:
          Name:
            NameFull: Wang X
      – PersonEntity:
          Name:
            NameFull: Waters A
      – PersonEntity:
          Name:
            NameFull: Waters L
      – PersonEntity:
          Name:
            NameFull: Watkins AH
      – PersonEntity:
          Name:
            NameFull: Olson P
      – PersonEntity:
          Name:
            NameFull: Smith CR
      – PersonEntity:
          Name:
            NameFull: Christensen JG
      – PersonEntity:
          Name:
            NameFull: Marx MA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 28
              M: 03
              Text: 2024 Mar 28
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 67
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1