Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.

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Title: Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.
Authors: Tonggu L; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA., Wisedchaisri G; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA., Gamal El-Din TM; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA., Lenaeus MJ; Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Logan MM; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.; Vividion Therapeutics, Inc., 5820 Nancy Ridge Dr., San Diego, CA, 92121, USA., Toma T; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.; PRISM BioLab Co., Ltd., 2-26-1 Muraokahigashi, Fujisawa-shi, Kanagawa, 251-8555, Japan., Du Bois J; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA., Zheng N; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA. nzheng@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA. nzheng@uw.edu., Catterall WA; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA. wcatt@uw.edu.
Source: Nature communications [Nat Commun] 2024 Mar 14; Vol. 15 (1), pp. 2306. Date of Electronic Publication: 2024 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Tonggu+L%22">Tonggu L</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Wisedchaisri+G%22">Wisedchaisri G</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Gamal+El-Din+TM%22">Gamal El-Din TM</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Lenaeus+MJ%22">Lenaeus MJ</searchLink>; Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Logan+MM%22">Logan MM</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.; Vividion Therapeutics, Inc., 5820 Nancy Ridge Dr., San Diego, CA, 92121, USA.<br /><searchLink fieldCode="AU" term="%22Toma+T%22">Toma T</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.; PRISM BioLab Co., Ltd., 2-26-1 Muraokahigashi, Fujisawa-shi, Kanagawa, 251-8555, Japan.<br /><searchLink fieldCode="AU" term="%22Du+Bois+J%22">Du Bois J</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+N%22">Zheng N</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA. nzheng@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA. nzheng@uw.edu.<br /><searchLink fieldCode="AU" term="%22Catterall+WA%22">Catterall WA</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA. wcatt@uw.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 Mar 14; Vol. 15 (1), pp. 2306. <i>Date of Electronic Publication: </i>2024 Mar 14.
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