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Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial.

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Title: Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial.
Authors: Nielsen FM; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Klitgaard TL; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark., Siegemund M; Department of Intensive Care and Department of Clinical Research, Basel University Hospital, Basel, Switzerland., Laake JH; Department of Anaesthesia and Intensive Care, Division of Emergencies and Critical Care, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway., Thormar KM; Department of Anesthesia and Intensive Care, Landspitali, University Hospital of Reykjavik, Reykjavik, Iceland., Cole JM; Department of Intensive Care, Cardiff University Hospital of Wales, Cardiff, Wales., Aagaard SR; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Bunzel AG; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark., Vestergaard SR; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark., Langhoff PK; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark., Pedersen CH; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark., Hejlesen JØ; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark., Abdelhamid S; Department of Intensive Care and Department of Clinical Research, Basel University Hospital, Basel, Switzerland., Dietz A; Department of Intensive Care and Department of Clinical Research, Basel University Hospital, Basel, Switzerland., Gebhard CE; Department of Intensive Care and Department of Clinical Research, Basel University Hospital, Basel, Switzerland., Zellweger N; Department of Intensive Care and Department of Clinical Research, Basel University Hospital, Basel, Switzerland., Hollinger A; Department of Intensive Care and Department of Clinical Research, Basel University Hospital, Basel, Switzerland., Poulsen LM; Department of Anaesthesia and Intensive Care, Zealand University Hospital, Køge, Denmark., Weihe S; Department of Anaesthesia and Intensive Care, Zealand University Hospital, Køge, Denmark., Andersen-Ranberg NC; Department of Anaesthesia and Intensive Care, Zealand University Hospital, Køge, Denmark., Pedersen UG; Department of Anaesthesia and Intensive Care, Zealand University Hospital, Køge, Denmark., Mathiesen O; Department of Anaesthesia and Intensive Care, Zealand University Hospital, Køge, Denmark., Andreasen AS; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Herlev, Denmark., Brix H; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Herlev, Denmark., Thomsen JJ; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Herlev, Denmark., Petersen CH; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Herlev, Denmark., Bestle MH; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, North Zealand, Hillerød, Denmark., Wichmann S; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, North Zealand, Hillerød, Denmark., Lund MS; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, North Zealand, Hillerød, Denmark., Mortensen KM; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, North Zealand, Hillerød, Denmark., Brand BA; Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Haase N; Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Iversen SA; Department of Anaesthesia and Intensive Care, Slagelse Hospital, Slagelse, Denmark., Marcussen KV; Department of Anaesthesia and Intensive Care, Slagelse Hospital, Slagelse, Denmark., Brøchner AC; Department of Anaesthesia and Intensive Care, Kolding Hospital, Kolding, Denmark., Borup M; Department of Anaesthesia and Intensive Care, Kolding Hospital, Kolding, Denmark., Grøfte T; Department of Anaesthesia and Intensive Care, Randers Hospital, Randers, Denmark., Hildebrandt T; Department of Anaesthesia and Intensive Care, Zealand University Hospital, Roskilde, Denmark., Kjær MN; Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Engstrøm J; Copenhagen Trial Unit, Centre for Clinical Intervention, Capital Region, Copenhagen University Hospital, Rigshospitalet, Denmark., Lange T; Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark., Perner A; Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Schjørring OL; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Rasmussen BS; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Corporate Authors: HOT-COVID Trial Group
Source: JAMA [JAMA] 2024 Apr 09; Vol. 331 (14), pp. 1185-1194.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1538-3598
DOI:10.1001/jama.2024.2934