Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming.

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Title: Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming.
Authors: Wu X; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China., Yuan H; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Wu Q; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Gao Y; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China., Duan T; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Yang K; Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA., Huang T; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Wang S; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Yuan F; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Lee D; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Taori S; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Plute T; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Heissel S; Proteomics Resource Center, the Rockefeller University, New York, NY, USA., Alwaseem H; Proteomics Resource Center, the Rockefeller University, New York, NY, USA., Isay-Del Viscio M; Proteomics Resource Center, the Rockefeller University, New York, NY, USA., Molina H; Proteomics Resource Center, the Rockefeller University, New York, NY, USA., Agnihotri S; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Hsu DJ; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Zhang N; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China. zhangnu2@mail.sysu.edu.cn., Rich JN; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. drjeremyrich@gmail.com.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. drjeremyrich@gmail.com.
Source: Nature cancer [Nat Cancer] 2024 Jul; Vol. 5 (7), pp. 1024-1044. Date of Electronic Publication: 2024 Mar 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-1347
DOI:10.1038/s43018-024-00748-7