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Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming.

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Title: Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming.
Authors: Wu X; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China., Yuan H; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Wu Q; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Gao Y; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China., Duan T; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Yang K; Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA., Huang T; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Wang S; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Yuan F; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Lee D; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Taori S; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Plute T; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Heissel S; Proteomics Resource Center, the Rockefeller University, New York, NY, USA., Alwaseem H; Proteomics Resource Center, the Rockefeller University, New York, NY, USA., Isay-Del Viscio M; Proteomics Resource Center, the Rockefeller University, New York, NY, USA., Molina H; Proteomics Resource Center, the Rockefeller University, New York, NY, USA., Agnihotri S; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Hsu DJ; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Zhang N; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China. zhangnu2@mail.sysu.edu.cn., Rich JN; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. drjeremyrich@gmail.com.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. drjeremyrich@gmail.com.
Source: Nature cancer [Nat Cancer] 2024 Jul; Vol. 5 (7), pp. 1024-1044. Date of Electronic Publication: 2024 Mar 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yuan+H%22">Yuan H</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Duan+T%22">Duan T</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Huang+T%22">Huang T</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+F%22">Yuan F</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Taori+S%22">Taori S</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Plute+T%22">Plute T</searchLink>; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Heissel+S%22">Heissel S</searchLink>; Proteomics Resource Center, the Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alwaseem+H%22">Alwaseem H</searchLink>; Proteomics Resource Center, the Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Isay-Del+Viscio+M%22">Isay-Del Viscio M</searchLink>; Proteomics Resource Center, the Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Molina+H%22">Molina H</searchLink>; Proteomics Resource Center, the Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Agnihotri+S%22">Agnihotri S</searchLink>; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+DJ%22">Hsu DJ</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangdong Translational Medicine Innovation Platform, Guangzhou, China. zhangnu2@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Rich+JN%22">Rich JN</searchLink>; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. drjeremyrich@gmail.com.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. drjeremyrich@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2024 Jul; Vol. 5 (7), pp. 1024-1044. <i>Date of Electronic Publication: </i>2024 Mar 22.
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