Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.
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| Title: | Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. |
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| Authors: | Sahu U; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Villa E; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Reczek CR; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Zhao Z; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., O'Hara BP; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Torno MD; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Mishra R; BioRankings, St. Louis, MO 63108, USA., Shannon WD; BioRankings, St. Louis, MO 63108, USA., Asara JM; Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Gao P; Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Shilatifard A; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Chandel NS; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Ben-Sahra I; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. |
| Source: | Science (New York, N.Y.) [Science] 2024 Mar 29; Vol. 383 (6690), pp. 1484-1492. Date of Electronic Publication: 2024 Mar 28. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adh2771 |
