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Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.

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Title: Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.
Authors: Sahu U; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Villa E; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Reczek CR; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Zhao Z; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., O'Hara BP; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Torno MD; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Mishra R; BioRankings, St. Louis, MO 63108, USA., Shannon WD; BioRankings, St. Louis, MO 63108, USA., Asara JM; Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Gao P; Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Shilatifard A; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Chandel NS; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Ben-Sahra I; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Source: Science (New York, N.Y.) [Science] 2024 Mar 29; Vol. 383 (6690), pp. 1484-1492. Date of Electronic Publication: 2024 Mar 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Sahu+U%22">Sahu U</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Villa+E%22">Villa E</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Reczek+CR%22">Reczek CR</searchLink>; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22O'Hara+BP%22">O'Hara BP</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Torno+MD%22">Torno MD</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Mishra+R%22">Mishra R</searchLink>; BioRankings, St. Louis, MO 63108, USA.<br /><searchLink fieldCode="AU" term="%22Shannon+WD%22">Shannon WD</searchLink>; BioRankings, St. Louis, MO 63108, USA.<br /><searchLink fieldCode="AU" term="%22Asara+JM%22">Asara JM</searchLink>; Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Gao+P%22">Gao P</searchLink>; Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Shilatifard+A%22">Shilatifard A</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Chandel+NS%22">Chandel NS</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Ben-Sahra+I%22">Ben-Sahra I</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2024 Mar 29; Vol. 383 (6690), pp. 1484-1492. <i>Date of Electronic Publication: </i>2024 Mar 28.
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