Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates.

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Title: Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates.
Authors: McArthur N; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Kang B; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Rivera Moctezuma FG; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Shaikh AT; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Loeffler K; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Bhatt NN; Mitchell Center for Neurodegenerative Disease, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, University of Texas Medical Branch, Galveston, Texas, USA., Kidd M; Mitchell Center for Neurodegenerative Disease, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, University of Texas Medical Branch, Galveston, Texas, USA., Zupancic JM; Department of Chemical Engineering, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA., Desai AA; Department of Chemical Engineering, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA., Djeddar N; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA., Bryksin A; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA., Tessier PM; Department of Chemical Engineering, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA.; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA., Kayed R; Mitchell Center for Neurodegenerative Disease, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, University of Texas Medical Branch, Galveston, Texas, USA., Wood LB; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA., Kane RS; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA.
Source: Biotechnology progress [Biotechnol Prog] 2024 Sep-Oct; Vol. 40 (5), pp. e3463. Date of Electronic Publication: 2024 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8506292 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6033 (Electronic) Linking ISSN: 15206033 NLM ISO Abbreviation: Biotechnol Prog Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1520-6033
DOI:10.1002/btpr.3463