Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants.
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| Title: | Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants. |
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| Authors: | Kuiper LM; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Shi W; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Verlouw J; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Hong YS; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Arp P; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Puiu D; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Broer L; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Xie J; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Newcomb C; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Rich SS; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Bader JS; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Guallar E; Department of Epidemiology and Medicine, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University Bloomberg School of Public Health. Baltimore, MD, USA., van Meurs JBJ; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.; Department of Orthopeadics & Sports Medicine, Erasmus MC, Rotterdam, the Netherlands., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2024 Apr 03. Date of Electronic Publication: 2024 Apr 03. |
| Publication Type: | Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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