A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.
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| Title: | A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance. |
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| Authors: | Hou S; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Chen J; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Feng R; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Xu X; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Liang N; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Champer J; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China. Electronic address: jchamper@pku.edu.cn. |
| Source: | Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2024 Aug; Vol. 51 (8), pp. 836-843. Date of Electronic Publication: 2024 Apr 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Science press Country of Publication: China NLM ID: 101304616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1673-8527 (Print) Linking ISSN: 16738527 NLM ISO Abbreviation: J Genet Genomics Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1673-8527 |
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| DOI: | 10.1016/j.jgg.2024.04.001 |
