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A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.

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Title: A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.
Authors: Hou S; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Chen J; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Feng R; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Xu X; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Liang N; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China., Champer J; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China. Electronic address: jchamper@pku.edu.cn.
Source: Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2024 Aug; Vol. 51 (8), pp. 836-843. Date of Electronic Publication: 2024 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Science press Country of Publication: China NLM ID: 101304616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1673-8527 (Print) Linking ISSN: 16738527 NLM ISO Abbreviation: J Genet Genomics Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.
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  Data: <searchLink fieldCode="AU" term="%22Hou+S%22">Hou S</searchLink>; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Feng+R%22">Feng R</searchLink>; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Liang+N%22">Liang N</searchLink>; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Champer+J%22">Champer J</searchLink>; Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China. Electronic address: jchamper@pku.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Science+press%22">Science press </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101304616 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1673-8527 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216738527%22">16738527 </searchLink><i>NLM ISO Abbreviation: </i>J Genet Genomics <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.jgg.2024.04.001
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      – Code: eng
        Text: English
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      – TitleFull: A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.
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              Text: 2024 Aug
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              Value: 8
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            – TitleFull: Journal of genetics and genomics = Yi chuan xue bao
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