Administration mode matters for 5-fluorouracil therapy: Physiologically based pharmacokinetic evidence for avoidance of myelotoxicity by continuous infusion but not intravenous bolus.
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| Title: | Administration mode matters for 5-fluorouracil therapy: Physiologically based pharmacokinetic evidence for avoidance of myelotoxicity by continuous infusion but not intravenous bolus. |
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| Authors: | Chao CJ; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan., Gardner I; Simcyp Division, Certara UK Limited, Sheffield, UK., Lin CJ; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan., Yeh KH; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan., Lu WC; Department of Pharmacy, MacKay Memorial Hospital, Taipei, Taiwan., Abduljalil K; Simcyp Division, Certara UK Limited, Sheffield, UK., Ho YF; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. |
| Source: | British journal of clinical pharmacology [Br J Clin Pharmacol] 2025 Apr; Vol. 91 (4), pp. 1031-1040. Date of Electronic Publication: 2024 Apr 16. |
| Publication Type: | Journal Article; Comparative Study |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1365-2125 |
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| DOI: | 10.1111/bcp.16061 |
