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BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis.

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Title: BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis.
Authors: Verkerke ARP; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Wang D; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Yoshida N; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Taxin ZH; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Shi X; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Zheng S; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Li Y; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Auger C; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Oikawa S; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Yook JS; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., Granath-Panelo M; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA., He W; Duke Molecular Physiology Institute, Duke School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Duke University, Durham, NC, USA., Zhang GF; Duke Molecular Physiology Institute, Duke School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Duke University, Durham, NC, USA., Matsushita M; Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo, Japan., Saito M; Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Gerszten RE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Mills EL; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Immunology, Harvard Medical School, Boston, MA, USA., Banks AS; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Ishihama Y; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., White PJ; Duke Molecular Physiology Institute, Duke School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., McGarrah RW; Duke Molecular Physiology Institute, Duke School of Medicine, Sarah W. Stedman Nutrition and Metabolism Center, Department of Medicine, Division of Cardiology, Duke University, Durham, NC, USA., Yoneshiro T; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan; Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan., Kajimura S; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA. Electronic address: skajimur@bidmc.harvard.edu.
Source: Cell [Cell] 2024 May 09; Vol. 187 (10), pp. 2359-2374.e18. Date of Electronic Publication: 2024 Apr 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Verkerke+ARP%22">Verkerke ARP</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yoshida+N%22">Yoshida N</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Taxin+ZH%22">Taxin ZH</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+X%22">Shi X</searchLink>; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+S%22">Zheng S</searchLink>; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Auger+C%22">Auger C</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Oikawa+S%22">Oikawa S</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yook+JS%22">Yook JS</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Granath-Panelo+M%22">Granath-Panelo M</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22He+W%22">He W</searchLink>; Duke Molecular Physiology Institute, Duke School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+GF%22">Zhang GF</searchLink>; Duke Molecular Physiology Institute, Duke School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Matsushita+M%22">Matsushita M</searchLink>; Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+M%22">Saito M</searchLink>; Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Gerszten+RE%22">Gerszten RE</searchLink>; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mills+EL%22">Mills EL</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Immunology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Banks+AS%22">Banks AS</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ishihama+Y%22">Ishihama Y</searchLink>; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22White+PJ%22">White PJ</searchLink>; Duke Molecular Physiology Institute, Duke School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22McGarrah+RW%22">McGarrah RW</searchLink>; Duke Molecular Physiology Institute, Duke School of Medicine, Sarah W. Stedman Nutrition and Metabolism Center, Department of Medicine, Division of Cardiology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Yoneshiro+T%22">Yoneshiro T</searchLink>; Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan; Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Kajimura+S%22">Kajimura S</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA. Electronic address: skajimur@bidmc.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2024 May 09; Vol. 187 (10), pp. 2359-2374.e18. <i>Date of Electronic Publication: </i>2024 Apr 22.
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